Comparative UV-Visible Spectrophotometric Analysis of Different Paracetamol Brands

Abstract

:  Paracetamol is a well-known analgesic and antipyretic drug available in different marketed brands in India. This study embraces a comparative assay of paracetamol (PCM) using UV-Visible Spectrophotometry, a widely used analytical technique for the analysis of pharmaceutical products. The assay focused on the quantification of PCM in various tablet formulations by measuring the absorbance of individual tablet solution at its characteristic wavelength (257nm). The percentage purity of the particular brand was determined by comparing the absorbance of the individual brand with the absorbance of the standard paracetamol. According to IP (Indian Pharmacopoeia) specifications, the percent purity of paracetamol should fall within the range of 95% to 105%.

The spectrophotometric assay revealed that samples A,B,C and D complied with the IP-specifiedpurity limit, while sample E was found to be outside the acceptable range.