COMPARATIVE UV-VISIBLE SPECTROPHOTOMETRIC ANALYSIS OF DIFFERENT PARACETAMOL BRANDS

Abstract

Paracetamol is a well-known analgesic and antipyretic drug available in different marketed brands in India.
This study embraces a comparative assay of paracetamol (PCM) using UV-Visible Spectrophotometry, a
widely used analytical technique for the analysis of pharmaceutical products. The assay focused on the
quantification of PCM in various tablet formulations by measuring the absorbance of individual tablet
solution at its characteristic wavelength(257nm). The percentage purity of the particular brand was
determined by comparing the absorbance of the individual brand with the absorbance of the standard
paracetamol. According to IP (Indian Pharmacopoeia) specifications, the percent purity of paracetamol
should fall within the range of 95% to 105%.
The spectrophotometric assay revealed that samples A, B, C and D complied with the IP-specified purity
limit, while sample E was found to be outside the acceptable range.