Developing A Rapid, Cost-Effective and Accurate Diagnostic Approach for Pulmonary and Extra Pulmonary Tuberculosis

Abstract

Global growth in multidrig-resistant tuberculosis (MDR-TB) demands rapid and accurate clinical equipment for effective disease control. “The purpose of this study was to detect genetic mutations in mycobacterium tuberculosis associated with drug resistance using MTBDRPLUS line probe assay”. Molecular testing identified mutations in RPOB (S531L) and KATG (S315T) genes, which confirms multidrig-resistant strains. The assay demonstrated high specificity and rapid results, aligning with phenotypeic conclusions. These results emphasize the value of molecular diagnosis in early identity, treatment guidance and epidemiological monitoring.